Hasnain says:

This is why ethics in ML and AI is so important. The paper is really ominous.

“The reality is that this is not science fiction. We are but one very small company in a universe of many hundreds of companies using AI software for drug discovery and de novo design. How many of them have even considered repurposing, or misuse, possibilities? Most will work on small molecules, and many of the companies are very well funded and likely using the global chemistry network to make their AI-designed molecules. How many people have the know-how to find the pockets of chemical space that can be filled with molecules predicted to be orders of magnitude more toxic than VX? We do not currently have answers to these questions. There has not previously been significant discussion in the scientific community about this dual-use concern around the application of AI for de novo molecule design, at least not publicly. Discussion of societal impacts of AI has principally focused on aspects such as safety, privacy, discrimination and potential criminal misuse10, but not on national and international security. When we think of drug discovery, we normally do not consider technology misuse potential. We are not trained to consider it, and it is not even required for machine learning research, but we can now share our experience with other companies and individuals. AI generative machine learning tools are equally applicable to larger molecules (peptides, macrolactones, etc.) and to other industries, such as consumer products and agrochemicals, that also have interests in designing and making new molecules with specific physicochemical and biological properties. This greatly increases the breadth of the potential audience that should be paying attention to these concerns.”

Posted on 2022-03-15T06:57:03+0000