Hasnain says:

This is such a sad and moving human interest story - interspersed with solid data around Alzheimer’s.

“People with these genetic mutations usually show symptoms around the same age as their parents. A 2012 study published in the New England Journal of Medicine traced the insidious groundwork of the disease through “biomarkers” detectable in the body long before symptoms surfaced. Twenty-five years before Jo would have noticed any major cognitive problems, the levels of amyloid in his cerebrospinal fluid would have begun to decline, as the protein began to accumulate in his brain. Jo would have been about 10 years old.”

Posted on 2020-02-14T03:50:22+0000